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EIF2S1, His tagged human

产品编号:4118441
规格:recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
CAS NO:480740-00-9
包装规格:50 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
411844150 μG4310
产品别名

480740-00-9

EIF2S1, His tagged human

EIF2A

EIF-2α

EIF-2

EIF2

EIF-2A

基本信息
NACRES
NA.32
General description【一般描述】
Eukaryotic translation initiation factor 2 subunit 1 α (EIF2S1) is a 35kDa protein. It is the α subunit of the eukaryotic initiation factor 2 (eIF2α). The gene encoding it is localized on human chromosome 14q23.3.
Biochem/physiol Actions【生化/生理作用】
Eukaryotic translation initiation factor 2 subunit 1 α (EIF2S1) catalyzes the first regulated step of protein synthesis initiation and promotes the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. The Ser51 in the mature human EIF2-α protein acts as the sole site of phosphorylation that leads to repression of protein synthesis. EIF2-α also plays an essential role in erythropoiesis.
Physical form【外形】
Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Preparation Note【制备说明】
after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in E. coli
Assay【测定】
≥70% (SDS-PAGE)
form【形式】
buffered aqueous glycerol solution
mol wt【分子量】
~40 kDa
NCBI accession no.【NCBI登记号】
NM_004094
application(s)
cell analysis
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... EIF2S1(1965)
安全信息
Pictograms【象形图】
GHS07,GHS08
Signal word【警示用语:】
Danger
Hazard Statements
H315 - H319 - H360D
Precautionary Statements
P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Hazard Classifications【危险分类】
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class Code【储存分类代码】
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
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