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Etoposide quinone
产品别名
105016-65-7
Etoposide quinone
Etoposide 3′,4′-quinone
Etoposide o-quinone
基本信息
| Empirical Formula【经验(实验)分子式】 | C28H28O13 |
| Molecular weight | 572.51 |
| General description【一般描述】 | Etoposide-quinone is a major metabolite of anticancer drug etoposide, which may contribute to the development of secondary acute myeloid leukemias in some etoposide patients. Etoposide-quinone is a covalent poison of human topoisomerase IIb, which induces four times more topoisomerase IIb mediated DNA cleavage than etoposide. Etoposide-quinone is a potent (IC50 = 7 μM) irreversible inhibitor of TCPTP protein tyrosine phosphatase that increases STAT1 tyrosine phosphorylation and contributes to etoposide dependent leukemogenesis. |
| Application【应用】 | Application: Metabolomics |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | synthetic |
| grade【等级】 | research grade |
| Assay【测定】 | ≥93% (H-NMR) |
| form【形式】 | solid |
| technique(s) | HPLC: suitable |
| color【颜色】 | dark red |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Pictograms【象形图】 | GHS07,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H302 - H350 - H361d |
| Precautionary Statements | P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Carc. 1B - Repr. 2 |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
