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ICAM1/CD54 human
产品编号: | 4119434 |
规格: | recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE) |
包装规格: | 100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
ICAM1/CD54 human
ICAM-1
BB-2
P3.58
BB2
基本信息
NACRES | NA.32 |
General description【一般描述】 | Inter-Cellular Adhesion Molecule 1 (ICAM-1), also known as Cluster of Differentiation 54 (CD54), is a member of the immunoglobulin superfamily, and is a cell surface glycoprotein which is typically expressed in low concentrations on endothelial cells and cells of the immune system. The protein encoded by this gene is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues. ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies. ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds. |
Physical form【外形】 | Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization. |
Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃. |
产品性质
biological source【生物来源】 | human |
recombinant【重组】 | expressed in HEK 293 cells |
Assay【测定】 | ≥98% (SDS-PAGE) |
form【形式】 | lyophilized |
mol wt【分子量】 | calculated mol wt 75.7 kDa (This protein is fused with Fc fragment of human IgG1 at the C-terminus.) observed mol wt 100-110 kDa by SDS-PAGE (reducing) (Gln 27 is the predicted N-terminal.) |
packaging【包装】 | pkg of 20 and 100 μg |
impurities【杂质】 | <1 EU/μg endotoxin (LAL test) |
UniProt accession no.【UniProt登记号】 | P05362 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... ICAM1(3383) |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |