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ICOSLG/B7-H2/CD275 human
产品编号: | 4119444 |
规格: | recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE) |
包装规格: | 20 μG,100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
ICOSLG/B7-H2/CD275 human
B7RP1
LICOS
B7H2
ICOS-L
ICOS ligand
ICOSL
B7RP-1
GL50
基本信息
NACRES | NA.32 |
General description【一般描述】 | ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. |
Physical form【外形】 | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization. |
Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃. |
产品性质
biological source【生物来源】 | human |
recombinant【重组】 | expressed in HEK 293 cells |
tag【标签】 | 6-His tagged (C-terminus) |
Assay【测定】 | ≥95% (SDS-PAGE) |
form【形式】 | lyophilized |
potency【效能】 | 3.2-400 ng/mL |
mol wt【分子量】 | calculated mol wt 27.5 kDa observed mol wt 45-50 kDa (DTT-reduced. Protein migrates due to glycosylation. Asp 19 is the predicted N-terminal.) |
packaging【包装】 | pkg of 20 and 100 μg |
impurities【杂质】 | <1 EU/μg |
UniProt accession no.【UniProt登记号】 | O75144 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... ICOSLG(23308) |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |