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IL17R/CD217 human
| 产品编号： | 4119486 |
| 规格： | recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE) |
| 包装规格： | 10 μG，50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
IL17R/CD217 human
CDw217
CANDF5
IL-17RA
IL17R
hIL-17R
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | Interleukin 17 receptor A (IL17RA), also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes. IL 17RA associates with IL 17RC to form a signaling receptor complex for IL17 and IL17F. Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5). The IL17RA (Interleukin 17 receptor A) gene is mapped to human chromosome 22q11.1 and is expressed ubiquitously and exhibits a broad tissue distribution. |
| Biochem/physiol Actions【生化/生理作用】 | Interleukin 17 receptor A (IL17RA) offers protection against pathogenic infection as it plays an important role in host defence mechanism. IL17RA deficiency might lead to the risk of chronic mucocutaneous candidiasis. IL-17A is a proinflammatory cytokine and its immune response is mediated by IL17RA. |
| Physical form【外形】 | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization. |
| Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| tag【标签】 | 6-His tagged (C-terminus) |
| Assay【测定】 | ≥98% (SDS-PAGE) |
| form【形式】 | lyophilized |
| mol wt【分子量】 | calculated mol wt 34.3 kDa observed mol wt 55-60 kDa (DTT-reduced. Protein migrates due to glycosylation. Leu 33 is the predicted N-terminal.) |
| packaging【包装】 | pkg of 10 and 50 μg |
| UniProt accession no.【UniProt登记号】 | Q96F46 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IL17RA(23765) |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
