您的位置：首页 > 产品中心 > Jagged-1 (human): FC (human)
Jagged-1 (human): FC (human)
| 产品编号： | 4119602 |
| 规格： | recombinant, expressed in HEK 293 cells, >90% (SDS-PAGE) |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Jagged-1 (human): FC (human)
Protein jagged-1
Tweak-receptor
JAG1
HJ1
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | Jagged-1, encoded by the gene JAG1, is a Serrate homolog found in vertebrates. It is expressed by both primitive and mature human hematopoietic cells. The encoded protein contains EGF (epidermal growth factor) repeats, transmembrane domain and a cysteine-rich region in between the two. Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF). |
| Application【应用】 | Jagged-1 has been used to activate Notch1 signaling pathway that modulates cardiac AMPK (5′ AMP-activated protein kinase) signaling cascade. Jagged-1 (human): FC (human) has been used to determine the cardiac substrate (fatty acid and glucose) metabolism in working heart model. |
| Biochem/physiol Actions【生化/生理作用】 | The encoded protein is a transmembrane-type ligand for Notch family receptor and is capable of inducing Notch signaling, which participates in embryogenesis, tissue regeneration, and carcinogenesis. Jagged-1 is a WNT-dependent Notch signaling activator that is involved in the maintenance of homeostasis of stem and progenitor cells. Jagged proteins are found to be involved in development and carcinogenesis. Overexpression of Jagged-1 has been observed in cervical and breast cancers. |
| Physical form【外形】 | Solution in PBS. |
| Other Notes【其他说明】 | Signal peptide and extracellular domain of human Jagged-1 (HJ1; CD339) (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG1. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| Assay【测定】 | >90% (SDS-PAGE) |
| form【形式】 | liquid |
| mol wt【分子量】 | ~150 kDa by SDS-PAGE |
| packaging【包装】 | pkg of 10 μg |
| storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
| concentration【浓度】 | ≥0.2 mg/mL |
| technique(s) | ligand binding assay: suitable |
| impurities【杂质】 | <0.1 EU/μg endotoxin, tested |
| UniProt accession no.【UniProt登记号】 | P78504 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... JAG1(182) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
