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MB49 Mouse Bladder Carcinoma Cell Line
| 产品编号： | 4120076 |
| 规格： | MB49 mouse urothelial carcinoma cell line is widely used as an in vitro and in vivo model of bladder cancer. |
| 包装规格： | 1X106 CELLS/VIAL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
MB49 Mouse Bladder Carcinoma Cell Line
MB-49
基本信息
| eCl@ss | 32011203 |
| NACRES | NA.81 |
| General description【一般描述】 | MB49 cells are derived from C57BL/Icrf-a’ mouse bladder epithelial cells that were transformed by a single 24-hour treatment with the chemical carcinogen 7, 12-dimethylbenz[a]anthracene (DMBA) on the second day of a long term primary culture . Transformed cells transplanted into syngeneic mice were shown to generate carcinomas . While of male origin, karyotype analyses indicate the loss of the Y chromosome in 100% of the cells analyzed . This abnormality is a frequent early event in human bladder cancer. A recent study indicates that MB49 cells recapitulate key features of sex differences in bladder tumor growth . MB49 implantation in mice resulted in significantly larger tumors in males than females. In the presence of dihydrotestosterone, MB49 cells exhibited enhanced proliferation in a dose-dependent manner. In contrast, MB49 cells were unresponsive to the pregnancy hormone, human chorionic gonadotrophin (hCG) . MB49 cells exhibit low to no expression of MHC-Class I and II molecules . However, upon exposure to IFN-, the expressions of MHC Class I and II are significantly upregulated . |
| Quality【质量】 | • Each vial contains ≥ 1X106 viable cells. • Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services. • Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services. • Cells are negative for mycoplasma contamination |
| Other Notes【其他说明】 | This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the "Academic Use Agreement" as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| technique(s) | cell culture | mammalian: suitable |
| shipped in【运输】 | ambient |
产品说明
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
