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Milli-Mark Anti-CD20 -FITC Antibody, clone B-Ly1

产品编号:4120274
规格:clone B-Ly1, Milli-Mark®, from mouse
包装规格:100 TESTS
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4120274100 TESTS4680
产品别名

Milli-Mark Anti-CD20 -FITC Antibody, clone B-Ly1

Membrane-spanning 4-domains subfamily A member 1

B-lymphocyte surface antigen B1

Leukocyte surface antigen Leu-16

Bp35

CD_antigen=CD20

基本信息
eCl@ss
32160702
NACRES
NA.44
General description【一般描述】
CD20 is a transmembrane, non-glycosylated protein expressed on B-cell precursors and mature B cells, but is lost following differentiation into plasma cells (Tedder, 1994). In resting B cells, CD20 appears in a 33 kDa non-phosphorylated form. After mitogen stimulation, CD20 becomes heavily phosphorylated (35-37 kDa isoforms), and it is a dominant phosphoprotein in activated B cells and B-cell lines (Zhou, 1995). The long N- and C-terminal ends of the protein are located on the cytoplasmic side of the membrane and only a minor portion of the protein is exposed on the cell surface (Tedder, 1994). Antibodies reacting with CD20 cytoplasmic epitopes are designated CD20cy (Zhou, 1995). It is suggested that CD20 plays a direct role in regulating the transmembrane conductive Ca 2+ flux of B cells which indicates a possible function for CD20 as a regulator of proliferation and differentiation (Tedder, 1994).
Specificity【特异性】
Antibody recognizes Human CD20 antigen.
Application【应用】
This Milli-Mark Anti-CD20 -FITC Antibody, clone B-Ly1 is validated for use in FC for the detection of CD20.
Research Sub Category
Immunoglobulins & Immunology
Research Category
Inflammation & Immunology
Quality【质量】
Evaluated by flow cytometry using human lymphocytes.
Physical form【外形】
Protein A purified
Purified Mouse monoclonal IgG1k conjugated to PE in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2
Analysis Note【分析说明】
Control
Human Lymphocytes
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information【法律信息】
MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
conjugate【偶联物】
FITC conjugate
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
B-Ly1, monoclonal
species reactivity
human
manufacturer/tradename
Milli-Mark®
technique(s)
flow cytometry: suitable
isotype【同位素/亚型】
IgG1κ
NCBI accession no.【NCBI登记号】
NP_690605.1
UniProt accession no.【UniProt登记号】
P11836
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
33 kDa (Zhou, 1995)
Storage and Stability【储存及稳定性】
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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