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PRMT6 active human
| 产品编号： | 4139948 |
| 规格： | recombinant, expressed in E. coli, ≥70% (SDS-PAGE) |
| 包装规格： | 20 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
PRMT6 active human
HRMT1L6
protein arginine N-methyltransferase 6
Histone-arginine N-methyltransferase 6
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | Protein arginine methyltransferase 6 (PRMT6) is a 41.9kDa protein with 375 amino acids. It is encoded by the gene mapped to human chromosome 1. It belongs to type I enzyme, which is a subclass of PRMT family. PRMT6 is localized exclusively in nucleus. Human PRMT6 (GenBank Accession No. NM_018137), amino-acids 2-375 (end), with N-terminal His-tag, MW=43kDa, expressed in Escherichia coli. |
| Application【应用】 | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Biochem/physiol Actions【生化/生理作用】 | Protein arginine methyltransferase 6 (PRMT6) catalyze the formation of asymmetric ω-NG,NG -dimethylarginine residues. In addition, PRMT6 show automethylation activity, which is unique among the members of PRMT family. PRMT6 mediates cigarette smoke extract (CSE)-triggered apoptosis and inflammation via di-methylation H3 arginine 2 (H3R2me2a) in human umbilical vein endothelial cells (HUVECs). PRMT6 plays a crucial role in various physiological processes such as transcriptional regulation, DNA repair and human immunodeficiency virus pathogenesis. Upregulated expression of the enzyme might be favorable for tumor growth and progression. Overexpression of PRMT6 has been observed in various type of malignancies including breast, cervix, bladder, prostate and lung cancer. |
| Physical form【外形】 | Formulated in 200 mM imidazole, 20% glycerol, and 3 mM DTT. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥70% (SDS-PAGE) |
| form【形式】 | aqueous solution |
| mol wt【分子量】 | 43 kDa |
| packaging【包装】 | pkg of 20 μg |
| NCBI accession no.【NCBI登记号】 | NM_018137 |
| UniProt accession no.【UniProt登记号】 | Q96LA8 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... PRMT6(55170) |
安全信息
| Pictograms【象形图】 | GHS07,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H315 - H319 - H360D |
| Precautionary Statements | P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 1 |
