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Progranulin human
| 产品编号： | 4139972 |
| 规格： | recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE) |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Progranulin human
PEPI
Activation-inducible TNF-related ligand
Proepithelin
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| conjugate【偶联物】 | untagged |
| Assay【测定】 | >95% (SDS-PAGE) |
| form【形式】 | lyophilized |
| mol wt【分子量】 | ~65 kDa by SDS-PAGE |
| packaging【包装】 | pkg of 10 μg |
| storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
| impurities【杂质】 | <0.1 EU/μg endotoxin, tested |
| color【颜色】 | white |
| UniProt accession no.【UniProt登记号】 | P28799 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... GRN(2896) |
基本信息
| General description【一般描述】 | Progranulin (PGRN) is a cysteine-rich protein with 593-amino acids and has a molecular weight of ~68.5kDa. The PGRN gene, with one non-coding exon and 12 coding exons spanning 8kb of genomic DNA, is mapped to human chromosome 17q21. The encoded protein is characterized by seven granulin-like domains, which include 7.5 highly conserved tandem repeats of a rare 12 cysteinyl residues. PGRN is predominantly expressed in rapidly cycling epithelial cells, leukocytes, neurons, and chondrocytes. |
| Biochem/physiol Actions【生化/生理作用】 | Progranulin (PGRN) is a widely expressed pluripotent growth factor, which plays a crucial role in various processes such as development, cell cycle progression, cell motility, wound repair and inflammation. Additionally, It is also implicated in early embryogenesis, host defense, cartilage development and degradation. Mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). PGRN expression is associated with the development of various type of cancer such as breast cancer, ovarian carcinoma, and multiple myeloma. Overexpression of PGRN has been observed in neurodegenerative diseases such as microglia of Creutzfeldt-Jacob patients and in spinal cord of amyotrophic lateral sclerosis (ALS) patients. |
| Physical form【外形】 | Lyophilized from 0.2 μm-filtered solution in PBS. |
| Reconstitution【重悬】 | Reconstitute with 100 μL deionized water. |
| Other Notes【其他说明】 | Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
