SIRT7, active, His tagged human

NA.32

SIRT7 is a member of the class IV of sirtuin family of proteins which are homologs to the yeast Sir2 protein and play a role in cell differentiation, proliferation, apoptosis, metabolism, and senescence. SIRT7 associates with active rRNA genes and histones. Overexpression of SIRT7 increases pol I-mediated transcription whereas knockdown of SIRT7 or inhibition of its catalytic activity results in decreased association of pol I with rDNA and reduced pol I transcription. Depletion of SIRT7 stops cell proliferation and triggers apoptosis. SIRT7 deacetylates p53 and increases cellular resistance to cytotoxic and oxidative stress.

Supplied in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol.

After opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles.

human

expressed in baculovirus infected Sf9 cells

≥70% (SDS-PAGE)

buffered aqueous glycerol solution

112-139 RLU/min·ng

~46 kDa

NM_016538

genomic analysis

dry ice

−70℃

human ... SIRT7(51547)

GHS07,GHS08

Danger

H315 - H319 - H360D

P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 1