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TNCA
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4141054 | 10 MG | 888 | |||
| 4141054 | 50 MG | 3140 |
产品别名
42438-90-4
TNCA
(3S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid
Lycoperodine-1
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C12H12N2O2 |
| Molecular weight | 216.24 |
| MDL number | MFCD00272641 |
| PubChem Substance ID【PubChem化学物质编号】 | 329826033 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| optical activity【旋光性】 | [α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1)) |
| color【颜色】 | white to beige |
| solubility【溶解性】 | 1.5 mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed) |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | O=C(O)[C@H]1NCC2=C(C3=C(N2)C=CC=C3)C1 |
| InChI | 1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16)/t10-/m0/s1 |
| InChI key | FSNCEEGOMTYXKY-JTQLQIEISA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
