TNFR1/CD120a/TNFRSF1A human

human

expressed in HEK 293 cells

6-His tagged (C-terminus)

≥92% (SDS-PAGE)

lyophilized

calculated mol wt 22 kDa
observed mol wt 30-35 kDa (DTT-reduced. Protein migrates due to different glycosylation. Ile 22 is the predicted N-terminus.)

pkg of 10 μg
pkg of 50 μg

<1 EU/μg endotoxin (LAL test)

P19438

wet ice

−20℃

human ... TNFRSF1A(7132)

Tumor necrosis factor receptor 1 (TNF-R1) also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-α and homotrimeric TNFSF1 / lymphotoxin - α. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial Hibernian fever (FHF).

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

11 - Combustible Solids

WGK 3