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ULBP2 human
| 产品编号： | 4141288 |
| 规格： | recombinant, expressed in E. coli, ≥85% (SDS-PAGE) |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
ULBP2 human
N2DL2
NKG2D ligand 2
RAET1H
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | ULBP2, also known as NKG2D ligand 2, belongs to the MHC class I family. This protein is ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. Recombinant human ULBP2 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
| Physical form【外形】 | 1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 30% glycerol, 2 M Urea and 2 mM DTT. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥85% (SDS-PAGE) |
| form【形式】 | liquid |
| mol wt【分子量】 | 24.3 kDa (216 aa, 26-216 aa + His Tag) |
| packaging【包装】 | pkg of 100 μg |
| concentration【浓度】 | 1 mg/mL |
| UniProt accession no.【UniProt登记号】 | Q9BZM5 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... ULBP2(80328) |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P264 - P280 - P305 + P351 + P338 - P337 + P313 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
