Meloxicam-CAS 71125-38-7-Calbiochem

C₁₄H₁₃N₃O₄S₂

351.40

A cell-permeable, non-steroidal anti-inflammatory drug (NSAID) of the oxicam family which preferentially inhibits the inducible isoform of COX-2 (IC₅₀ = 4.7 µM) relative to COX-1 (IC₅₀ = 36.6 µM). Also inhibits the growth of colorectal cancer cells in vitro.
A cell-permeable, non-steroidal, anti-inflammatory drug (NSAID) of the oxicam family that preferentially inhibits the inducible isoform of cyclooxygenase-2 (COX-2; IC₅₀ = 4.7 µM) relative to cyclooxygenase-1 (COX-1; IC₅₀ = 36.6 µM). Also inhibits the growth of colorectal cancer cells in vitro.

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 4.7 µM, 36.6 µM against the inducible isoform of COX-2 relative to COX-1, respectively
Primary Target
COX-2

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

Blanco, F.J., et al. 1999. J. Rheumatol. 26, 1366.
Davies, N.M., and Skjodt, N.M. 1999. Clin. Pharmacokinet. 36, 115.
Goldman, A.P., et al. 1998. Carcinogenesis 19, 2195.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

off-white

DMSO: 10 mg/mL

ambient

2-8℃

1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,19H,1-2H3,(H,15,16)/b13-11+

DWMREKMVXIFPFM-ACCUITESSA-N

100 mg in Plastic ampoule
Packaged under inert gas

GHS06

Danger

H301

P264 - P270 - P301 + P310 - P405 - P501

Acute Tox. 3 Oral

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 2