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C5 Lenalidomide
产品别名
191732-70-4
C5 Lenalidomide
Ligand for PROTAC research
E3 Ligase ligand
3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C13H13N3O3 |
| Molecular weight | 259.26 |
| MDL number | MFCD31692701 |
| Application【应用】 | C5 Lenalidomide is a derivative of the Cereblon (CRBN)-binding ligand lenalidomide, which possesses an amine at the C4 position. C5 Lenalidomide can be used to bind the CRBN E3 ubiquitin ligase in targeted protein degradation research or in the synthesis of protein degraders with a C5 exit vector. Learn more about proteolysis-targeting chimeras (PROTACs) and the building blocks to design them in our Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation |
| Other Notes【其他说明】 | Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC® Degraders for Targeted Protein Degradation Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production Targeted Protein Degradation by Small Molecules |
| Legal Information【法律信息】 | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
产品性质
| Assay【测定】 | ≥95% |
| form【形式】 | powder |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | NC1=CC=C2C(CN(C3CCC(NC3=O)=O)C2=O)=C1 NC1=CC=C2C(CN(C3CCC(NC3=O)=O)C2=O)=C1 |
安全信息
| Pictograms【象形图】 | GHS08 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H361d - H373 |
| Precautionary Statements | P201 - P308 + P313 |
| Hazard Classifications【危险分类】 | Repr. 2 - STOT RE 2 |
| Target Organs【靶器官】 | Blood |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
