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Calcineurin Autoinhibitory Peptide-Calbiochem
| 产品编号： | 4144255 |
| 规格： | The Calcineurin Autoinhibitory Peptide controls the biological activity of Mn2+-stimulated calcineurin activity. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| 包装规格： | 250 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Calcineurin Autoinhibitory Peptide-Calbiochem
ITSFEEAKGLDRINERMPPRRDAMP
基本信息
| Empirical Formula【经验(实验)分子式】 | C124H205N39O39S2 |
| Molecular weight | 2930.32 |
| General description【一般描述】 | Corresponds to a C-terminal domain (residues 457-482) of the calmodulin-binding domain of calcineurin. Specific calcineurin inhibitor. Does not inhibit CaM kinase II, protein phosphatase I or 2A. Inhibits Mn2+-stimulated calcineurin activity (IC50 = 10 µM using 32P myosin light chain as a substrate) but has no effect on Ni2+-stimulated activity. Specific calcineurin inhibitor. Corresponds to the C-terminal domain (residues 457-482) of the calmodulin-binding domain of calcineurin (PP2B). Inhibits Mn2+-stimulated calcineurin activity (IC50 = 10 µM using 32P-myosin light chain as a substrate) but has no effect on Ni2+-stimulated enzyme activity. Does not inhibit CaM kinase II, protein phosphatase 1 or 2A. |
| Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Primary Target Mn2+-stimulated calcineurin activity Reversible: no Cell permeable: no Target IC50: 10 µM using 32P-myosin light chain as a substrate |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | H-Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys-Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-OH |
| Physical form【外形】 | Supplied as a trifluoroacetate salt. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 months at -20°C. |
| Other Notes【其他说明】 | Perrino, B.A., et al. 1995. J. Biol. Chem. 270, 340. Yokoyama, Y., and Wang, J.H. 1994. FEBS Lett.337, 128. Yokoyama, N., et al. 1993. Arch. Biochem. Biophys.300, 615. Matsui, H., et al. 1991. Biochem. Int.24, 1119. Hashimoto, Y., et al. 1990. J. Biol. Chem.265, 1924. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | lyophilized |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| solubility【溶解性】 | water: soluble |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 250 μg in Plastic ampoule Yes |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
