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Congo Red, High Purity-CAS 573-58-0-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4144421 | 500 MG | 1390 |
产品别名
573-58-0
Congo Red, High Purity-CAS 573-58-0-Calbiochem
3,3'-[(1,1'-Biphenyl)-4,4'-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na
基本信息
| Empirical Formula【经验(实验)分子式】 | C32H22N6O6S2 · 2Na |
| Molecular weight | 696.66 |
| MDL number | MFCD00004028 |
| General description【一般描述】 | An amyloidophylic dye that specifically stains stacked β sheet aggregates. Useful for staining and visual detection of amyloid deposits. Does not bind to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the metabolism of the normal isoform. It is also shown to inhibit Pot1 Binding to Telomeric DNA. An amyloidophylic dye that specifically stains stacked β sheet aggre-gates. Useful for staining and visual detection of amyloid deposits in nerve tissue. Binds to amyloid fibrils but not to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the normal isoform possibly through overstabilization of the conformation. It is also shown to inhibit Pot1 Binding to Telomeric DNA. |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target An amyloidophylic dye that specifically stains stacked β sheet aggregates Product does not compete with ATP. Reversible: no Cell permeable: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C). |
| Other Notes【其他说明】 | Altschuler, S.E., et al. 2012. Biochemistrin press. Khurana, R., et al. 2001. J. Biol. Chem.276, 22715. Fezoui, Y., et al. 2000. Amyloid7, 166. Fezoui, Y., et al. 2000. Nat. Struct. Biol.7, 1095. Kramport, M., et al. 2000. Chem. Biol.7, 855. Kuner, P., et al. 2000. J. Biol. Chem.275, 1673. Caspi, S., et al. 1998. J. Biol. Chem.273, 3484. Caughey, B., and Race, A.E. 1992. J. Neurochem.59, 768. Taylor, D.L., et al. 1974. J. Histochem. Cytochem.22, 1105. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥75% dye basis |
| form【形式】 | crystalline solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | rust |
| solubility【溶解性】 | water: 10 mg/mL ethanol: soluble |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 15-25℃ |
| InChI | 1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2 |
| InChI key | IQFVPQOLBLOTPF-UHFFFAOYSA-L |
| packaging【包装】 | 500 mg in Glass bottle |
安全信息
| Pictograms【象形图】 | GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H350 - H361d |
| Precautionary Statements | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
| Hazard Classifications【危险分类】 | Carc. 1B - Repr. 2 |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
