Diethyl Pyrocarbonate-CAS 1609-47-8-Calbiochem

C₆H₁₀O₅

162.14

MFCD00009106

Inhibits ryanodine binding to ryanodine/Ca²⁺ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca²⁺ permeability of SR vesicles. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
Inhibits ryanodine binding to ryanodine/Ca²⁺ receptor channel in skeletal muscle. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.

Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle

Toxicity: Harmful (C)

Shoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
Blumbers, D.O. 1987. Methods Enzymol. 152, 20.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (titration)

liquid

Calbiochem^®

OK to freeze
protect from light

clear colorless

chloroform: soluble
ethanol: soluble

ambient

2-8℃

1S/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H3

FFYPMLJYZAEMQB-UHFFFAOYSA-N

25 g in Plastic ampoule
100 g in Glass bottle

GHS07

Warning

H302

P264 - P270 - P301 + P312 - P501

Acute Tox. 4 Oral

10 - Combustible liquids

WGK 3

156.2 °F - closed cup

69 ℃ - closed cup