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tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate
产品别名
909422-39-5
tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate
Semi-flexible linker for PROTAC development
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H25NO3 |
| Molecular weight | 291.39 |
| MDL number | MFCD30099260 |
| Application【应用】 | tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. |
| Other Notes【其他说明】 | Portal: Building PROTAC® Degraders for Targeted Protein Degradation Crosslinkers for Bioconjugation Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation |
| Legal Information【法律信息】 | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% |
| form【形式】 | powder |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(N(CC1)CCC1C2=CC(CO)=CC=C2)OC(C)(C)C |
安全信息
| Pictograms【象形图】 | GHS07,GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H317 - H319 - H410 |
| Precautionary Statements | P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
