TRAIL, Human, Recombinant, E. coli

≥95% (SDS-PAGE)

100

liquid

Calbiochem^®

OK to freeze
avoid repeated freeze/thaw cycles

<0.1 EU/μg endotoxin (EU/μg TRAIL)

wet ice

−70℃

100 μg in Plastic ampoule
Please refer to vial label for lot-specific concentration.

Recombinant, human TRAIL (amino acids 114-281) expressed in E. coli. Ligand for TRAIL receptors DR4 and DR5. Displays potent antitumor activity against selected targets and induces apoptosis in a number of transformed cell lines, but not in normal tissues.

Induces apoptosis in U937 cells at 1 μg/ml within 5 h.

Toxicity: Standard Handling (A)

In 500 mM NaCl, 10 mM Na₂HPO₄, 2.7 mM KCl, 2 mM KH₂PO₄, 0.1 mM DTT, ≤10% glycerol.

Following initial thaw, aliquot and freeze

(-70°C).

Lin, Y., et al. 2000. Mol. Cell. Biol.20, 6638.
Mitsaides, N., et al. 2000. Cancer Res.60, 4122.
Griffith, T.S., et al. 1999. J. Exp. Med.189, 1343.
Mariani, S.M., et al. 1997. J. Cell Biol.137, 221.
Pan, G., et al. 1997. Science276, 111.
Pan, G., et al. 1997. Science277, 815.
Sheridan, J.P., et al. 1997. Science277, 818.
Pitti, R.M., et al. 1996. J. Biol. Chem.271, 12687.
Wiley, S.R., et al. 1995. Immunity3, 673.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

11 - Combustible Solids

WGK 1