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ALLM-CAS 110115-07-6-Calbiochem
| 产品编号： | 4152157 |
| 规格： | Cell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). |
| CAS NO： | 110115-07-6 |
| 包装规格： | 25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4152157 | 25 MG | 3940 |
产品别名
110115-07-6
ALLM-CAS 110115-07-6-Calbiochem
Calpain Inhibitor II
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H35N3O4S |
| Molecular weight | 401.56 |
| General description【一般描述】 | A cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Cell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A weak inhibitor of proteasome. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target Ki: 120 nM, 230 nM, 100 nM, and 600 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively Product does not compete with ATP. Reversible: no Primary Target calpain-1 |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | N-Acetyl-Leu-Leu-Met |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Ravid, T., et al. 2000. J. Biol. Chem.275, 35840. Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721. Sarin, A., et al. 1994. J. Immunol.153, 862. Sarin, A., et al. 1993. J. Exp. Med. 178, 1693. Banik, N.L., et al. 1992. Neurochem. Res.17, 797. Koohmaraie, M. 1992. Biochemie74, 239. Pinter, M., et al. 1992. Biochemistry31, 8201. Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol.138, 24. Sasaki, T., et al. 1990. J. Enzyme Inhib.3, 195. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | >95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | off-white |
| solubility【溶解性】 | DMSO: 5 mg/mL ethanol: 5 mg/mL methanol: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1 |
| InChI key | RJWLAIMXRBDUMH-ULQDDVLXSA-N |
| packaging【包装】 | 25 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
