Angiogenesis Inhibitor-CAS 186611-44-9-Calbiochem

C₁₂H₉N₃O

211.22

A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model). The potency has been reported to be comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).
A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).

Cell permeable: yes
Target IC₅₀: 54% inhibition at 10 µM against hEGF-R tyrosine kinase activity
Reversible: no
Product competes with ATP.
Primary Target
hEGF-R tyrosine kinase activity

Toxicity: Carcinogenic / Teratogenic (D)

Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem.18, 243.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

yellow

DMSO: 5 mg/mL

ambient

2-8℃

10 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1