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Baicalein-CAS 491-67-8-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4155235 | 10 MG | 2380 |
产品别名
491-67-8
Baicalein-CAS 491-67-8-Calbiochem
5,6,7-Trihydroxyflavone
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H10O5 |
| Molecular weight | 270.24 |
| MDL number | MFCD00017459 |
| General description【一般描述】 | A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50 = 120 nM) and reverse transcriptase. Protects cortical neurons from β-amyloid induced toxicity. Reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Also inhibits cellular Ca2+ uptake and mobilization, and adjuvant-induced arthritis. Reported to inhibit microsomal lipid peroxidation by forming an iron-baicalein complex. Inhibits topoisomerase II and induces cell death in hepatocellular carcinoma cell lines. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated protein kinase C. A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50 = 120 nM) and reverse transcriptase. Reduces leukotriene biosynthesis and the release of lysosomal enzymes. Also inhibits cellular Ca2+ uptake and mobilization, and adjuvant-induces arthritis. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated PKC. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target 12-lipoxygenase Product does not compete with ATP. Reversible: no Target IC50: 120 nM against 12-lipoxygenase |
| Warning【警告】 | Toxicity: Irritant (B) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. |
| Other Notes【其他说明】 | Leabeau, A., et al. 2001. Neuroreport12, 2199. Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215. Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170. Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73. Butenko, I.G., et al. 1993. Agents Actions 39, C49. Abe, K., et al. 1990. Chem. Pharm. Bull.38, 209. Kimura, Y., et al. 1987. Biochim. Biophys. Acta922, 278. Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun.105, 1090. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: 20 mg/mL acetone: soluble |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H |
| InChI key | FXNFHKRTJBSTCS-UHFFFAOYSA-N |
| packaging【包装】 | 10 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
