MreB Perturbing Compound A22-CAS 22816-60-0-Calbiochem

C₈H₈Cl₂N₂S · xHCl

235.13 (free base basis)

MFCD00035050

A cell-permeable isothiourea compound that specifically, rapidly, and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with the nucleotide binding pocket of MreB and is useful for the temporal analysis of MreB function.
A cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with MreB′s nucleotide binding pocket and is useful for the temporal analysis of MreB function.

Cell permeable: yes
Product does not compete with ATP.
Reversible: yes
Primary Target
MreB

Toxicity: Standard Handling (A)

Following reconstitution in DMSO, aliquot and freeze (-20°C. DMSO stock solutions are stable for up to 1 month at -20°C. Reconstitute in H₂O just prior to use; aqueous stock solutions are stable for up to 12 hr. Stable for up to 2 days in acidic medium.

Gitai, Z., et al. 2005. Cell120, 329.
Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol.3, 167.
Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem.66, 2658.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)
protect from light

white

water: 2 mg/mL
DMSO: 200 mg/mL

ambient

2-8℃

1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H

VBJNMXMOMSWRDV-UHFFFAOYSA-N

25 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3