Nimodipine-CAS 66085-59-4-Calbiochem

C₂₁H₂₆N₂O₇

418.44

MFCD00153848

An L-type Ca²⁺ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats.
An L-type Ca²⁺ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats. Also reported to block TNF-α and LPS-induced iNOS activity (IC₅₀ = 36 pM) in mouse astroglial cells.

Product does not compete with ATP.
Reversible: no
Primary Target
L-type Ca2⁺ channel blocker
Cell permeable: no
Target IC₅₀: 36 pM blocking TNF-α and LPS-induced iNOS activity in mouse astroglial cells

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Zhu, D., et al. 1999. Life. Sci.65, PL 221.
Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
Kappelle, A.C., et al. 1994. Br. J. Pharmacol.111, 887.
Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
Kappelle, A.C., et al. 1993. Br. J. Pharmacol.108, 780.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

>98% (TLC)

solid

Calbiochem^®

OK to freeze
protect from light

yellow

DMSO: 25 mg/mL
methanol: soluble

ambient

2-8℃

1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3

UIAGMCDKSXEBJQ-UHFFFAOYSA-N

25 mg in Plastic ampoule

GHS07

Warning

H302

P264 - P270 - P301 + P312 - P501

Acute Tox. 4 Oral

11 - Combustible Solids

WGK 1