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NMDAR2C/2D Inhibitor, DQP-1105-Calbiochem
| 产品编号： | 4168100 |
| 规格： | The NMDAR2C/2D Inhibitor, DQP-1105 controls the biological activity of NMDAR2C/2D. This small molecule/inhibitor is primarily used for Neuroscience applications. |
| 包装规格： | 10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
NMDAR2C/2D Inhibitor, DQP-1105-Calbiochem
NMDA Antagonist IV, DQP-1105
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C29H24BrN3O4 |
| Molecular weight | 558.42 |
| MDL number | MFCD02989065 |
| General description【一般描述】 | A dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC50 = 5.4 µM) and GluN1/GluN2D (2.2 µM) over GluN1/GluN2B (206 µM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC50 values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine. |
| Warning【警告】 | Toxicity: Regulatory Review (Z) |
| Other Notes【其他说明】 | Acker, T., et al. 2011. Mol. Pharmacol.80, 782. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | yellow-white |
| solubility【溶解性】 | DMSO: 10 mg/mL, pale yellow |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | O=C(O)CCC(N1N=C(C2=C(C3=CC=CC=C3)C4=C(NC2=O)C=CC(C)=C4)CC1C5=CC=C(Br)C=C5)=O |
| packaging【包装】 | 10 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
