p38 MAP Kinase Inhibitor IV-CAS 1638-41-1-Calbiochem

C₁₂H₄Cl₆O₄S

456.94

A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC₅₀ = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 µM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 µM respective inhibitor).
A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC₅₀ = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 µM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 µM respective inhibitor).

Toxicity: Harmful (C)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Liu, Y.C., et al. 2007. Biochem. Biophys. Res. Commun.352, 656.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)
protect from light

light yellow

DMSO: 4.5 mg/mL

ambient

2-8℃

10 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3