p38 MAP Kinase Inhibitor VII, SD-169-CAS 1670-87-7-Calbiochem

C₉H₈N₂O

160.17

MFCD07779486

A cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38α MAP kinase inhibitor (IC₅₀ = 3.2 nM). It inhibits p38β only at much higher concentrations (IC₅₀ = 122 nM) and exhibits little activity against p38γ, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 µM. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.

Toxicity: Harmful (C)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Medicherla, S., et al. 2006. J. Pharmacol. Exp. Ther.318, 99.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

off-white

water: 1 mg/mL
DMSO: 10 mg/mL

ambient

2-8℃

10 mg in Plastic ampoule
Packaged under inert gas

GHS07

Warning

H302 - H315 - H319 - H335

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Respiratory system

11 - Combustible Solids

WGK 3