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Propargyl-PEG2-acid
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产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4168641 | 50 MG | 1670 |
产品别名
1859379-85-3
Propargyl-PEG2-acid
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C8H12O4 |
Molecular weight | 172.18 |
NACRES | NA.22 |
Application【应用】 | Propargyl-PEG2-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG2-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation. This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains two PEG units to help improve solubility. |
Legal Information【法律信息】 | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
产品性质
form【形式】 | liquid |
reaction suitability | reaction type: click chemistry |
storage temp.【储存温度】 | −20℃ |
SMILES string | C#CCOCCOCCC(O)=O |
安全信息
Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
WGK | WGK 3 |