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Ras/Rac Transformation Blocker, SCH 51344-CAS 171927-40-5-Calbiochem
| 产品编号： | 4168760 |
| 规格： | A cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. |
| CAS NO： | 171927-40-5 |
| 包装规格： | 10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
171927-40-5
Ras/Rac Transformation Blocker, SCH 51344-CAS 171927-40-5-Calbiochem
6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H20N4O3 |
| Molecular weight | 316.36 |
| General description【一般描述】 | A cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a Kd of 49 nM and inhibit its catalytic activity (IC50 for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively). |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target Ras/Rac Product does not compete with ATP. Reversible: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Other Notes【其他说明】 | Huber, K. V. M., et al. 2014. Nature In press. He, H., et al. 1998. Mol. Cell. Biol.18, 3829. Walsh, A.B., et al. 1997. Oncogene15, 2553. Chandra Kumar, C., et al. 1995. Cancer Res.55, 5106. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | light yellow |
| solubility【溶解性】 | DMSO: 20 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 10 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
