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SILuTMLite CCL2 C-C motif chemokine 2 human
| 产品编号： | 4169068 |
| 规格： | recombinant, expressed in HEK 293 cells, MS Protein Standard |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
SILuTMLite CCL2 C-C motif chemokine 2 human
Monocyte secretory protein JE
HC11
Monocytechemoattractantprotein1
Monocyte chemotactic protein 1(MCP-1)
Small-inducible cytokine A2
Monocytechemotacticandactivatingfactor(MCAF)
Monocyte chemoattractant protein 1
基本信息
| NACRES | NA.12 |
| General description【一般描述】 | CCL2, the most thoroughly characterized CC chemokine, is a monocyte-specific chemoattractant that was demonstrated to attract T lymphocytes and NK cells, but not neutrophils. Enhanced expression of CCL2 was demonstrated in a variety of pathologic conditions, associated with inflammation and mononuclear cell infiltration. Extensive experimental evidence suggests that CCL2 is highly expressed in atherosclerotic plaques. In a recent study, CCL2 was shown to have value as a biomarker for risk stratification in both the initial and the chronic phases after an acute coronary syndromes (ACS). In contrast to CRP, CCL2 levels may be an indicator of long-term cardiovascular risk rather than a marker of acute prognosis. In urine, CCL2 levels were directly associated to Systemic Lupus Erythematosus disease activity, making it a non-invasive biomarker (avoiding blood sampling or tissue biopsies). |
| Immunogen【免疫原】 | QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKTDYKDDDDKGHHHHHHHHGGQ |
| Biochem/physiol Actions【生化/生理作用】 | SILu™Lite CCL2 is a recombinant human protein expressed in human 293 cells. It is a homodimer consisting of 96 amino acids (including C-terminal polyhistidine and FLAG® tags), with a calculated molecular mass of 11 kDa. SILu Lite CCL2 is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications. |
| Physical form【外形】 | Lyophilized from a solution of phosphate buffered saline. |
| Legal Information【法律信息】 | FLAG is a registered trademark of sigma-aldrich Co. LLC SILu is a trademark of sigma-aldrich Co. LLC |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| Assay【测定】 | ≥98% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| potency【效能】 | ≥98% Heavy amino acids incorporation efficiency by MS |
| technique(s) | mass spectrometry (MS): suitable |
| suitability【适用性】 | suitable for mass spectrometry (internal calibrator) |
| UniProt accession no.【UniProt登记号】 | P13500 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CCL2(6347) |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
