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SILuTMLite HAVCR1 Hepatitis A virus cellular receptor 1 human
| 产品编号： | 4169073 |
| 规格： | recombinant, expressed in HEK 293 cells, MS Protein Standard |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
SILuTMLite HAVCR1 Hepatitis A virus cellular receptor 1 human
T-cell immunoglobulin mucin receptor 1 (TIM-1)
T-cell immunoglobulin and mucin domain-containing protein 1 (TIMD-1)
Kidney injury molecule 1 (KIM-1)
基本信息
| NACRES | NA.12 |
| General description【一般描述】 | HAVCR1 is a trans-membrane glycoprotein that is highly expressed in kidney proximal tubular cells with kidney injury. The KIM-1 ectodomain is cleaved, released into urine, and canbe quantified as a sensitive and specific biomarker for Acute Kidney Injury (AKI) in rodents and humans. In a recent study it was demonstrated that HAVCR1 is released into the circulation where it reports kidney injury in mice, rats, and humans with AKI and chronic kidney disease (CKD). Urinary HAVCR1 and MCP-1 levels, either alone or in combination, were significantly higher than those in AKI negative patients. Importantly, the combination of HAVCR1 and MCP-1 outperformed either biomarker alone. |
| Immunogen【免疫原】 | SVKVGGEAGPSVTLPCHYSGAVTSMCWNRGSCSLFTCQNGIVWTNGTHVTYRKDTRYKLLGDLSRRDVSLTIENTAVSDSGVYCCRVEHRGWFNDMKITVSLEIVPPKVTTTPIVTTVPTVTTVRTSTTVPTTTTVPTTTVPTTMSIPTTTTVLTTMTVSTTTSVPTTTSIPTTTSVPVTTTVSTFVPPMPLPRQNHEPVATSPSSPQPAETHPTTLQGAIRREPTSSPLYSYTTDGNDTVTESSDGLWNNNQTQLFLEHSLLTANTTKGDYKDDDDKGHHHHHHHHGGQ |
| Biochem/physiol Actions【生化/生理作用】 | SILu™Lite HAVCR1 is a recombinant human protein expressed in human 293 cells. It is a protein consisting of 290 amino acids acids (the extracellular domain: Ser21-Gly290, and including C-terminal polyhistidine and FLAG® tags), with a calculated molecular mass of 31 kDa. SILu Lite HAVCR1 is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications. |
| Physical form【外形】 | Supplied as a lyophilized powder containing phosphate buffered saline. |
| Legal Information【法律信息】 | FLAG is a registered trademark of sigma-aldrich Co. LLC SILu is a trademark of sigma-aldrich Co. LLC |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| tag【标签】 | 8-His tagged |
| Assay【测定】 | ≥98% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| potency【效能】 | ≥98% Heavy amino acids incorporation efficiency by MS |
| mol wt【分子量】 | calculated mol wt 31 kDa |
| technique(s) | mass spectrometry (MS): suitable |
| suitability【适用性】 | suitable for mass spectrometry (internal calibrator) |
| UniProt accession no.【UniProt登记号】 | Q96D42 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... HAVCR1(26762) |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
