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SILuTMLite IGFBP7 Insulin-like growth factor-binding protein 7 human
| 产品编号： | 4169075 |
| 规格： | recombinant, expressed in HEK 293 cells, MS Protein Standard |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
SILuTMLite IGFBP7 Insulin-like growth factor-binding protein 7 human
IGF-bindingprotein7
IGFBP-7
PGI2-stimulating factor
Tumor-derived adhesion factor (TAF)
IBP-7
IGFBP-rP1
MAC25 protein
Prostacyclin-stimulating factor
IGF-binding protein 7
基本信息
| NACRES | NA.12 |
| General description【一般描述】 | SILu™ Lite IGFBP7 is a recombinant human protein expressed in human 293 cells. It is a protein consisting of 267 amino acids (including an N-terminal polyhistidine tag), with a calculated molecular mass of 28 kDa. SILu Lite IGFBP7 is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications. IGFBP7 (insulin-like growth factor-binding protein 7) belongs to the IGFBP superfamily and is widely expressed in tissues. It contains 11 cysteines, a heparin binding site, a kazal-type trypsin inhibitor domain and a carboxyl-terminal immunoglobulin-like type C repeat. IGFBP7 binds weakly to IGFs (insulin like growth factors) and strongly to insulin. It mainly participates in IGF-independent pathways. The IGFBP7 gene is mapped to human chromosome 4q12. |
| Immunogen【免疫原】 | HHHHHHHHGGQSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALHEIPVKKGEGAEL |
| Biochem/physiol Actions【生化/生理作用】 | SILu™Lite IGFBP7 is a recombinant human protein expressed in human 293 cells. It is a protein consisting of 267 amino acids (including an N-terminal polyhistidine tag), with a calculated molecular mass of 28 kDa. SILu Lite IGFBP7 is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications. IGFBP7 (insulin-like growth factor-binding protein 7) acts as a tumor suppressor as well as an oncogene by controlling cell proliferation, cell attachment, apoptosis and angiogenesis. It is also involved in TGFβ (transforming growth factor beta) signal pathway. IGFBP7 interferes with the insulin pathway and is associated with the development of diabetes as well as cardiovascular diseases. |
| Physical form【外形】 | Supplied as a lyophilized powder containing phosphate buffered saline. |
| Legal Information【法律信息】 | SILu is a trademark of sigma-aldrich Co. LLC |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| Assay【测定】 | ≥98% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| potency【效能】 | ≥98 Heavy amino acids incorporation efficiency by MS |
| technique(s) | mass spectrometry (MS): suitable |
| suitability【适用性】 | suitable for mass spectrometry (internal calibrator) |
| UniProt accession no.【UniProt登记号】 | Q16270 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IGFBP7(3490) |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
