您的位置：首页 > 产品中心 > Wnt 拮抗剂 III，Box5-Calbiochem
Wnt 拮抗剂 III，Box5-Calbiochem
Wnt Antagonist III, Box5-Calbiochem
| 产品编号： | 4170543 |
| 规格： | The Wnt Antagonist III, Box5 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications. |
| 包装规格： | 10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Wnt 拮抗剂 III，Box5-Calbiochem
Wnt Antagonist III, Box5-Calbiochem
Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist, Wnt-5a Antagonist
基本信息
| Empirical Formula【经验(实验)分子式】 | C30H50N6O13S2 |
| Molecular weight | 766.88 |
| General description【一般描述】 | A Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | t-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Jenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA106, 19473. Safholm, A., et al. 2006. J. Biol. Chem.281, 2740. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥90% (HPLC) |
| form【形式】 | lyophilized solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | water: 4 mg/mL DMSO: 50 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 10 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
